Peroxiredoxin 1 Antibody

• Catalog number
  R30865
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Peroxiredoxin 1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Peroxiredoxin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Peroxiredoxin 1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q06830
• Purity
  Antigen affinity
• Description
  Peroxiredoxin 1, also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of a family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. PRDX1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. Immunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.
• Immunogen
  An amino acid sequence from the C-terminus of human PRDX1 (KPDVQKSKEYFSKQK) was used as the immunogen for this Peroxiredoxin 1 antibody.
• Storage
  After reconstitution, the Peroxiredoxin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Peroxiredoxin  
• Gene symbol
  PRDX4P1, PRDX1, PRDX2P1
• Short name
  Anti-Peroxiredoxin 1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Peroxiredoxin 1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:43598
• Gene
  PRDX4P1
• Long gene name
  peroxiredoxin 4 pseudogene 1
• Locus
  4p12
• Discovery year
  2011-11-23
• Entrez gene record
  100418949
• VEGA ID
  OTTHUMG00000162177

Gene info

• Identity
  HGNC:9352
• Gene
  PRDX1
• Long gene name
  peroxiredoxin 1
• Synonyms gene
  • PAGA
• Synonyms
  • NKEFA
• GenBank acession
  • BC021683
• Locus
  1p34.1
• Discovery year
  1993-11-01
• Entrez gene record
  5052
• Pubmed identfication
  • 8496166
• RefSeq identity
  • NM_181697
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000007738

Gene info

• Identity
  HGNC:30020
• Gene
  PRDX2P1
• Long gene name
  peroxiredoxin 2 pseudogene 1
• Locus
  13q12.3
• Discovery year
  2003-12-19
• Entrez gene record
  359844
• Pubmed identfication
  • 7607688
• RefSeq identity
  • NG_002915
• VEGA ID
  OTTHUMG00000016666

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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