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Target antigen
ASIC3
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
rat Predicted to work with: mouse
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ASIC3(56-73aa FLYQVAERVRYYREFHHQ), different from the related rat and mouse sequences by two amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the ASIC3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The ASIC3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
ASIC3(Acid-Sensing Ion Channel3), also known as TESTIS SODIUM CHANNEL 1(TNAC1) or DORSAL ROOT ACID-SENSING ION CHANNEL(DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the ACCN3 gene to chromosome 7q35. De Weille et al.(1998) found that human ASIC3 supported an H(+)-gated cation current in COS cells with kinetics similar to those of rat Asic3. Babinski et al.(1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH.
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Related articles
1. Babinski, K., Le, K.-T., Seguela, P. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J. Neurochem. 72: 51-57, 1999. 2. Birdsong, W. T., Fierro, L., Williams, F. G., Spelta, V., Naves, L. A., Knowles, M., Marsh-Haffner, J., Adelman, J. P., Almers, W., Elde, R. P., McCleskey, E. W. Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron 68: 739-749, 2010. 3. de Weille, J. R., Bassilana, F., Lazdunski, M., Waldmann, R. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. FEBS Lett. 433: 257-260, 1998.
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Gene Name
ASIC3
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Protein Name
Acid-sensing ion channel 3
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Gene Full Name
acid-sensing(proton-gated) ion channel 3
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Synonyms
ACCN 3 antibody|ACCN3 antibody|ACCN3_HUMAN antibody|Acid sensing ion channel 3 antibody|Acid-sensing ion channel 3 antibody|Amiloride sensitive cation channel 3 antibody|Amiloride sensitive cation channel 3 testis antibody|Amiloride-sensitive cation channel 3 antibody|ASIC 3 antibody|ASIC3 antibody|DRASIC antibody|hASIC 3 antibody|hASIC3 antibody|hTNaC 1 antibody|hTNaC1 antibody|Modulatory subunit of ASIC 2a antibody|Modulatory subunit of ASIC2a antibody|Neuronal amiloride sensitive cation channel 3 antibody|Neuronal amiloride-sensitive cation channel 3 antibody|Proton gated cation channel subunit antibody|SLNAC 1 antibody|SLNAC1 antibody|Testis sodium channel 1 antibody|TNaC 1 antibody|TNaC1 antibody
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Uniprot ID
Q9UHC3
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
