Ro3280
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Catalog numberB1175-5
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PricePlease ask
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Size5 mg
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Alternative_name4-((9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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DescriptionRO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1 (IC₅₀ = 3 nM).
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CAS Number1062243-51-9
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Structure AvailableYes
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Molecular FormulaC₂₇H₃₅F₂N₇O₃
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Molecular Weight543.61
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent, highly selective inhibitor of Polo-like kinase 1
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID25015677
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SMILESCN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC
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InChiInChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33)
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InChi KeyDJNZZLZKAXGMMC-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameRo3280
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Alternative nameRo3280
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