AG-120 (Ivosidenib)
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Catalog numberB1163-25
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PricePlease ask
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Size25 mg
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Alternative_name(2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
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DescriptionAG-120 is a potent isocitrate dehydrogenase type 1 (IDH1) inhibitor, with potential antineoplastic activity. Upon oral administration it specifically inhibits a mutated form of IDH1 in the cytoplasm inhibiting the formation of oncometabolite, 2-hydroxyglutarate (2HG). This leads to induction of cellular differentiation and an inhibition of cellular proliferation
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CAS Number1448347-49-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₈H₂₂ClF₃N₆O₆
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Molecular Weight582.97
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>5 mg/ml))
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HandlingProtect from air and light
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Tag LineA potent isocitrate dehydrogenase type 1 (IDH1) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID89699486
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SMILESC1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
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InChi1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25?/m0/s1
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InChi KeyWIJZXSAJMHAVGX-XADRRFQNSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolTPBG, COPZ1, BCAP31, FYB1
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Short nameAG-120 (Ivosidenib)
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Alternative nameAG-120 (Ivosidenib)
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Gene info
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Identity
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Gene
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Long gene nametrophoblast glycoprotein
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-10-16
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCOPI coat complex subunit zeta 1
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Synonyms gene
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Synonyms gene name
- coatomer protein complex, subunit zeta
- coatomer protein complex, subunit zeta 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-28
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Entrez gene record
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RefSeq identity
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Classification
- COPI coat complex
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameB cell receptor associated protein 31
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-12-22
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFYN binding protein 1
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Synonyms gene
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Synonyms gene name
- FYN-binding protein (FYB-120/130)
- FYN binding protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-04-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases