AG-120 (Ivosidenib)

  • Catalog number
    B1163-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
  • Description
    AG-120 is a potent isocitrate dehydrogenase type 1 (IDH1) inhibitor, with potential antineoplastic activity. Upon oral administration it specifically inhibits a mutated form of IDH1 in the cytoplasm inhibiting the formation of oncometabolite, 2-hydroxyglutarate (2HG). This leads to induction of cellular differentiation and an inhibition of cellular proliferation
  • CAS Number
    1448347-49-6
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₈H₂₂ClF₃N₆O₆
  • Molecular Weight
    582.97
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>5 mg/ml))
  • Handling
    Protect from air and light
  • Tag Line
    A potent isocitrate dehydrogenase type 1 (IDH1) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    89699486
  • SMILES
    C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
  • InChi
    1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25?/m0/s1
  • InChi Key
    WIJZXSAJMHAVGX-XADRRFQNSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    TPBG, COPZ1, BCAP31, FYB1
  • Short name
    AG-120 (Ivosidenib)
  • Alternative name
    AG-120 (Ivosidenib)
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    COPI coat complex subunit zeta 1
  • Synonyms gene
  • Synonyms gene name
    • coatomer protein complex, subunit zeta
    • coatomer protein complex, subunit zeta 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-09-28
  • Entrez gene record
  • RefSeq identity
  • Classification
    • COPI coat complex
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
Gene info
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