TPCK, Serine protease inhibitor
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Catalog number
SIH-207-500MG
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Price
Please ask
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Size
500 mg
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Stock availabilitIn Stock
In Stock
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CAS number
402-71-1
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Description
Serine protease inhibitor
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Molecular weight
351,85 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
N-(4-Chloro-3-oxo-1-phenyl-2-butanyl)-4-methylbenzenesulfonamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C17H18CI3O3S
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO (>10 mg/ml) and in 10 mM in methanol and ethanol (50 mg/ml)
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: 37/38-41 Hazard Phrases: H315-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
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PubChem number
9824
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Scientific context
Tosyl phenylalanyl chloromethyl ketone is a protease inhibitor. It also inhibits some cysteine proteases (1).
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Bibliography
1. Farrelll S.O., Campbell M.K. (2006) Biochemistry. Australia: Thomson Brooks/Cole. P.160.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of TPCK (SIH-207), a Serine protease inhibitor. CAS #: 402-71-1. Molecular Formula: C17H18CI3O3S. Molecular Weight: 351.85 g/mol. Chemical structure of TPCK, a Serine protease inhibitor (SIH-207). CAS # 402-71-1. Molecular Formula: C17H18CI3O3S.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.5
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+
3 form under biological conditions), a carboxyl group. It is non-essential in humans, meaning the body can synthesize it.
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Gene target
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Short name
TPCK, Serine protease inhibitor
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Alternative name
TPCK, Serine protease suppressor
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