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17-AAG, Hsp90 inhibitor

17-AAG, Hsp90 inhibitor is available 1 time from Stressma labs

SIH-100A | 17-AAG, Hsp90 inhibitor size: 1 mg | 292.70 USD

Catalog number SIH-100A
Supplier stressma
Price 292.70 USD
Size 1 mg
1. Gene info
Identity8841
GenePEPE
Long gene namepeptidase E
Locus17
Discovery year1986-01-01
Stock availabilitIn Stock In Stock
CAS number 75747-14-7
Description Hsp90 inhibitor
Molecular weight 585,7 g/mol
Primary research fields Cancer, Heat Shock
Other name 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-AAG, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin
Product category Small Molecules
Product type Inhibitor
Chemical formula C31H43N3O8
Origin Synthetic
Purity pourcentage >98%
Soluble in Soluble in DMSO (>20 mg/ml) or methanol (10 mg/ml)
Physical appearance Purple Solid
Storage recommendations -20ºC
Shipping recommendations Shipped Ambient
Safety information Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem number 6505803
Scientific context Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at more.
Bibliography 1. Neckers L. (2002) Trends Mol Med. 84: S55-61. 2. Kamal A., et al.(2003) Nature. 425: 407. 3. Solit D.B., et al.(2003) Cancer Res. 63: 2139. 4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 65: 235. 5. Jia W., et al.(2003) Blood. 102: 1824.
PubMed number Refer to PubMed
Tested applications To be tested
Tested reactivity To be tested
Representative figure legend Chemical structure of 17-AAG (SIH-100), a Hsp90 inhibitor. CAS #: 75747-14-7. Molecular Formula: C31H43N3O8. Molecular Weight: 585.7 g/mol. Chemical structure of 17-AAG, a Hsp90 inhibitor (SIH-100). CAS # 75747-14-7. Molecular Formula: C31H43N3O8.
Warning information Non-hazardous
Country of production Canada
Total weight (kg) 0.25
Net weight (g) 0.001
Additional description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene target17-AAG Hsp90 inhibitor
Short name 17-AAG, Hsp90 inhibitor
Alternative name 17-AAG, Hsp90 suppressor
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