NMNAT1, human recombinant

• Catalog number
  7561-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransferase 1; EC 2.7.7.1.
• Alternative_names
  Nicotinamide Mononucleotide Adenylyl-transferase 1, NMN Adenylyltransferase 1; NaMN Adenylyltransferase 1; EC 2.7.7.1.
• Description
  Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP.
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Biological activity
  ≥ 5U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min.
• Results
  ≥ 5U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min.
• Unit Definition
  One unit is defined as the amount of enzyme that synthesizes 1 µmol of NAD+ per min.
• Molecular Weight
  ~33.3 kDa (monomer). Human full-length NMNAT1 (aa 1-279) is fused at the N-terminus to a His-tag.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  6 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml in 50 mM sodium phosphate, pH 8.0 containing 300 mM sodium chloride, 2 mM DTT and 10% glycerol.
• Background Information
  This is the nuclear NMNAT isoform. It catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. It interacts with PARP-1/ARTD1. It protects against axonal degeneration following mechanical or toxic insults. It is widely expressed.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  NMNAT1  
• Gene symbol
  NMNAT1
• Short name
  NMNAT1, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  NMNAT1, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:17877
• Gene
  NMNAT1
• Long gene name
  nicotinamide nucleotide adenylyltransferase 1
• Synonyms gene
  • LCA9
• Synonyms gene name
  • nicotinamide nucleotide adenylyltransferase
  • Leber congenital amaurosis 9
  • Leber's congenital amaurosis 9
• Synonyms
  • NMNAT
  • PNAT1
• Synonyms name
  • nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
• GenBank acession
  • AF312734
• Locus
  1p36.22
• Discovery year
  2002-02-19
• Entrez gene record
  64802
• Pubmed identfication
  • 11248244
  • 11027696
  • 22842227
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000001799

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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