Vatalanib Dihydrochloride
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Catalog number
2025-25
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Price
Please ask
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Size
25 mg
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Alternative_name
CGP-79787; PTK 787; ZK222584
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Description
Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
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CAS Number
212141-51-0
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₀H₁₅ClN₄•2HCl
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Molecular Weight
419.73
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 10-20 mg/ml) or H₂O (~ 100 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A potent inhibitor of the VEGFR tyrosine kinases
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD08458964
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PubChem CID
22386467
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SMILES
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
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InChi
InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19 (24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
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InChi Key
AZUQEHCMDUSRLH-UHFFFAOYSA-N
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MSDS Available
Yes
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