Vatalanib Dihydrochloride

Alternative_name

CGP-79787; PTK 787; ZK222584
Description

Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
CAS Number

212141-51-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₅ClN₄•2HCl
Molecular Weight

419.73
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~ 10-20 mg/ml) or H₂O (~ 100 mg/ml)
Handling

Protect from air and moisture
Tag Line

A potent inhibitor of the VEGFR tyrosine kinases
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD08458964
PubChem CID

22386467
PubChem CID Link
SMILES

C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
InChi

InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19 (24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChi Key

AZUQEHCMDUSRLH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes