Recombinant Human IL-1 beta / IL1B Protein (pro form, His tag)

  • Catalog number
    PKSH031840-20µg
  • Price
    Please ask
  • Size
    20µg
  • Synonym
    IL-1;IL-1 beta;IL-1B;IL1-BETA;IL1F2
  • Activity
    Measured by its binding ability in a functional ELISA.2. Immobilized human IL1B at 10 μg/mL (100 μl/well) can bind human IL1RThe EC50 of human IL1R1 is 0.198 μg/mL.
  • Sequence
    Met 1-Ser 269
  • Fusion tag
    N-His
  • Accession
    NP_000567.1
  • Expressed Host
    E. coli
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    >95 % as determined by SDS-PAGE
  • Endotoxin
    Please contact us for more information.
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    32.3 kDa
  • AP Mol Mass
    34 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene
    The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Rec. E. coli interleukin-1 for cell culture or antibody production.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    IL-1   beta   IL1B   Protein   pro   form   His   tag  
  • Gene symbol
    IL1B, IL1A, IL1F10, IL36B, IL36A, IL19, IL17F, IL36G, IL25, IL22
  • Short name
    Recombinant IL-1 beta / IL1B Protein (pro form, His tag)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    His
  • Species
    Human, Humans
  • Alternative name
    Rec. H. sapiens Interleukin-1 b / interleukin 1, beta Protein (L-proline form, histidine detection labelled)
  • Alternative technique
    rec
  • Alternative to gene target
    interleukin 1, beta, IL-1 and IL1-BETA and IL1F2, IL1B and IDBG-66519 and ENSG00000125538 and 3553, protein domain specific binding, Extracellular, Il1b and IDBG-205936 and ENSMUSG00000027398 and 16176, IL1B and IDBG-634613 and ENSBTAG00000001321 and 281251
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MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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