PHYHIP Antibody, ALEXA FLUOR 488
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Catalog number
bs-11925R-A488
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Price
Please ask
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Size
100ul
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Long name
PHYHIP Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
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Also known as
Anti-PHYHIP PAb ALEXA FLUOR 488
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 488
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
PHYHIP
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Specificity
This is a highly specific antibody against PHYHIP.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Subcellular location
Extracellular
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PHYHIP
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
PHYHIP (Phytanoyl-CoA hydroxylase-interacting protein) is a 330 amino acid protein that is strongly expressed in brain, with weak expression in ovary, small intestine and ovary. In transgenic mice, overexpression of PHYHIP in heart results in tachycardia and tachyarrhythmia. PHYHIP interacts with the Refsum disease gene product, PAHX, indicating that PHYHIP may play a role in the CNS deficits of Refsum disease, which is characterized by cerebellar degeneration, neurologic damage and peripheral neuropathies. PHYHIP also interacts with Dyrk1A, a protein that that is overexpressed in brain of Down-syndrome patients, therefore PHYHIP may participate in some of the neurological abnormalities of Down syndrome. Significantly, the gene encoding PHYHIP is localized to a region of the short arm of human chromosome 8 that is frequently found deleted in prostate, breast and several other types of cancers.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
499nm/519nm
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Synonyms
DYRK1A interacting protein 3; DYRK1AP3; PAHX AP1; PAHXAP1; phytanoyl CoA 2 hydroxylase interacting protein; phytanoyl CoA alpha hydroxylase associated protein; Phytanoyl CoA hydroxylase associated protein 1; Phytanoyl CoA hydroxylase interacting protein; Similar to a putative C.elegans gene encoded in cosmid M01B2; PHYIP_HUMAN.
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Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-PHYHIP has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor
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French translation
anticorps
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Gene target
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Gene symbol
PHYHIP
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Short name
Anti-PHYHIP
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 488
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Alternative name
PHYHIP Polyclonal Antibody, ALEXA FLUOR 488
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Alternative technique
antibodies
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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