EXOSC10/PMSCL2 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-13120R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  EXOSC10/PMSCL2 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-EXOSC10/PMSCL2 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  EXOSC10/PMSCL2
• Specificity
  This is a highly specific antibody against EXOSC10/PMSCL2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
• Gene ID Number
  5394
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3’ region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3’-5’ enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  Autoantigen PM/Scl 2; Exosc10; Exosome component 10; EXOSX_HUMAN; P100 polymyositis scleroderma overlap syndrome associated autoantigen; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; p2; p3; p4; PM Scl; PM/Scl 100; PM/Scl-100; PMSCL; PMSCL2; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2 100 kDa; Polymyositis/scleroderma autoantigen 2; RRP6; Rrp6p.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-EXOSC10/PMSCL2 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  EXOSC10/PMSCL2  
• Gene symbol
  EXOSC10-AS1, EXOSC10
• Short name
  Anti-EXOSC10/PMSCL2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  EXOSC10/PMSCL2 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:40456
• Gene
  EXOSC10-AS1
• Long gene name
  EXOSC10 antisense RNA 1
• Locus
  1p36.22
• Discovery year
  2018-09-26
• Entrez gene record
  105376736
• RefSeq identity
  • NR_135061
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:9138
• Gene
  EXOSC10
• Long gene name
  exosome component 10
• Synonyms gene
  • PMSCL2
• Synonyms gene name
  • polymyositis/scleroderma autoantigen 2, 100kDa
• Synonyms
  • PM-Scl
  • PM/Scl-100
  • Rrp6p
  • RRP6
  • p2
  • p3
  • p4
• Synonyms name
  • polymyositis/scleroderma autoantigen 2 (100kD)
• GenBank acession
  • BC073788
• Locus
  1p36.22
• Discovery year
  1994-09-19
• Entrez gene record
  5394
• Pubmed identfication
  • 1383382
  • 1644924
• RefSeq identity
  • NM_001001998
• Classification
  • Exosome complex
• VEGA ID
  OTTHUMG00000002123

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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