BTLA/B-andT-lymphocyte attenuator/CD272(Fc fusion)
-
Catalog number
E21-D06
-
Price
Please ask
-
Size
10ug
-
-
Shipping_Temperature
Ambient
-
Product_State
Lyophilized
-
Formulation_Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
-
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
-
Purity
Greater than 95% as determined by reducing SDS-PAGE.
-
Endotoxin
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
-
Background
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
-
Alternative Names
B- and T-Lymphocyte Attenuator; B- and T-Lymphocyte-Associated Protein; CD272; BTLA
-
Expression system
Human cells
-
Description
Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes that originally coded for separate proteins. A GFP gene is often used as tag to a reporter gene. Fusion lentiverctors can be used as viral particles to produce proteins that carry for example a GFP tag. Antigen purification of recombinant fusion tag proteins is a frequent strategy using a Fralg tag.
-
Gene target
-
Gene symbol
BTLA
-
Short name
BTLA/B-andT-lymphocyte attenuator/CD272(Fc )
-
Technique
FC
-
Species
Human
-
Alternative name
B and T lymphocyte associated/B-andT-lymphocyte attenuator/CD272(fragment c fusion)
-
Alternative to gene target
B and T lymphocyte associated, BTLA and IDBG-49858 and ENSG00000186265 and 151888, protein binding, Cell surfaces, Btla and IDBG-162900 and ENSMUSG00000052013 and 208154, BTLA and IDBG-632288 and ENSBTAG00000011871 and 531767
-
Tissue
lymphocyte
-
Gene info
Similar products
