Indirubin-3'-monoxime, GSK, CDK kinase inhibitor

  • Catalog number
    SIH-502-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    160807-49-8
  • Description
    GSK, CDK kinase inhibitor
  • Molecular weight
    277,3 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    Indirubin-3'-monoxime, 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, Indirubin-3′-oxime
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C16H11N3O2
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Physical appearance
    Red solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    5326739
  • Scientific context
    Indirubin-3'-monoxime is an inhibitor of protein kinases and cyclin-dependent kinases. Specifically, it is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β).
  • Bibliography
    1. Damiens E., Baratte B., Marie D., Eisenbrand G., & Meijer L. (2001) Oncogene. 20(29): 3786–3797.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Indirubin-3'-monoxime (SIH-502), a GSK-3b and CDK kinase inhibitor. CAS #: 160807-49-8. Molecular Formula: C16H11N3O2. Molecular Weight: 277.3 g/mol. Chemical structure of Indirubin-3'-monoxime, a GSK-3b and CDK kinase inhibitor (SIH-502). CAS # 160807-49-8. Molecular Formula: C16H11N3O2.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Indirubin-3'-monoxime, GSK, CDK kinase inhibitor
  • Alternative name
    Indirubin-3'-monoxime, GSK, CDK phosphorylation catalyst suppressor
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