Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
This is a highly specific antibody against SLK Tyr530.
1ug per 1ul
KLH conjugated synthetic phosphopeptide derived from human FYN around the phosphorylation site of Tyr530
Gene ID Number
Human, Mouse, Rat
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen
Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1. The unique N terminal domain of Fyn interacts with the CD3 and eta chains of the TcR. Fyn can bind to other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.
Purified by Protein A.
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Fyn phospho Y530; p-Fyn phospho Y530; C syn protooncogene; FYN oncogene related to SRC FGR YESï¼› MGC45350ï¼› OKT3 induced calcium influx regulatorï¼› P59 FYN; Protein tyrosine kinase fyn; Proto oncogene tyrosine protein kinase fyn; Protooncogene Syn; SLK; Src like kinase; Src yes related novel gene; Src/yes related novel gene; SYN; FYN; Tyrosine kinase p59fyn T; Tyrosine kinase p59fynT.
Immunoglobulin G (IgG)
Alternative to gene target
STE20-like kinase, bA16H23.1 and LOSK and se20-9 and STK2, SLK and IDBG-88663 and ENSG00000065613 and 9748, transferase activity, Cytoplasm, Slk and IDBG-174800 and ENSMUSG00000025060 and 20874, SLK and IDBG-639375 and ENSBTAG00000001017 and 535342