MK-8745

  • Catalog number
    B1942-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone
  • Description
    MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
  • CAS Number
    885325-71-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₀H₁₉ClFN₅OS
  • Molecular Weight
    431.91
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>18 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    An Aurora-A specific inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    11676373
  • SMILES
    C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F
  • InChi
    InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
  • InChi Key
    YCRFPWKUUNKNDN-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
    MK-8745  
  • Gene symbol
    MVK, STYXL1, MDK, MAPKAPK3, EPCAM
  • Short name
    MK-8745
  • Alternative name
    MK-8745
Gene info
Gene info
Gene info
Gene info
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