(-)-JQ1
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Catalog number2384-1
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PricePlease ask
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Size1 mg
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Alternative_namet-Butyl-2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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DescriptionCell-permeable. A useful negative control for the BET bromodomain inhibitor (+)-JQ1 (Cat.No.2070). (−)-JQ1 enantiomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively.
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CAS Number1268524-71-5
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₃H₂₅ClN₄O₂S
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Molecular Weight456.99
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~10 mg/ml)
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HandlingProtect from light and air
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Tag LineA negative control for (+)-JQ1 (Cat. No. 2070).
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID49871818
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SMILESCC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
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InChiInChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1
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InChi KeyDNVXATUJJDPFDM-QGZVFWFLSA-N
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MSDS AvailableYes
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Gene target
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Short name(-)-JQ1
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Alternative name(-)-JQ1
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