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Tubastatin A for cell activation

Tubastatin A for cell activation is available 0 time from Biovision labs

Description Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC₅₀ values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 µM with near complete protection at 10 µM.
Peptide sequence N/A
CAS number 1239262-52-2
Molecular weight 371.86
Category Biochemicals
Other name n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide
Molecular formula C₂₀H₂₁N₃O₂.HCl
Physical appearance Off-white solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO (~90 mg/ml) or Water (~ 4mg/ml) or 2% TWEEN-80/water (~2 mg/ml) or 30% PEG (avg. MW = 400 g/mol)/50 mM phosphate buffer (pH = 2.25) (25 mg/ml) (heating is required to initially dissolve the compound).
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 24 months
Storage instructions Protect from air and light
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetTubastatin for activation
Short name Tubastatin A for activation
Technique activation
Alternative name Tubastatin A to measure cellular activation
Tissue cell
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