Harmine

• Catalog number
  2561-250
• Price
  Please ask
• Size
  250 mg

• Alternative_name
  7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
• Description
  Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.
• CAS Number
  442-51-3
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₃H₁₂N₂O
• Molecular Weight
  212.25
• Cell Permeable
  Yes
• Purity
  ≥98% by titration
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A MAO-A and DYRK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00004958
• PubChem CID
  5280953
• PubChem CID Link
• SMILES
  CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
• InChi
  InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
• InChi Key
  BXNJHAXVSOCGBA-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Harmine  
• Short name
  Harmine
• Alternative name
  Harmine

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