TCR, alpha, beta (T Cell Receptor, T-cell Receptor beta-1 Chain C Region, TRBC1, T-cell Receptor alpha Chain C Region, TRAC, TCRA) (FITC) Antibody

• Catalog number
  GEN609897
• Price
  Please ask
• Size
  100ug

• Also known as
  TCR, alpha, beta
• Other names
  TCR, partial; N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  N/A
• Gene name synonims
  N/A
• Other gene names
  N/A
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1
• Clone
  3H2918
• Host organism
  Mouse (Mus musculus)
• Source organism
  Rat (Rattus norvegicus)
• Species reactivity
  Monkey, Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes rat TCR, alpha, beta. Detects a T cell specific molecule consisting of two disulphide-linked subunits of 40 and 46kD molecular weight, respectively, on 97% of peripheral rat T cells as defined by the OX-52 marker. 3H2918 is mitogenic for unseparated spleen cells and for purified T cells. In the rat thymus, mature medullary cells express the 3H2918 determinant at the same level as peripheral T cells, whereas 94% of CD4- CD8- thymocytes are 3H2918 negative. It is most likely directed at a constant determinant of the rat alpha/beta heterodimeric T cell antigen receptor. Species Crossreactivity: Cynomolgus monkey; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  Highly Purified by Ion Exchange chromatography.
• Form Appearance
  Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 1% BSA. Conjugated to FITC.
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer. FITC conjugates are sensitive to light.
• Tested applications
  Flow Cytometry (FC/FACS)
• Description
  The TCR, alpha, beta (T Receptor, T- Receptor beta-1 Chain C Region, TRBC1, T- Receptor alpha Chain C Region, TRAC, TCRA) (FITC) Antibody is a α- or alpha protein sometimes glycoprotein present in blood. For cells, cell lines and tissues in culture till half confluency. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This MBS Monoclonals Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. MBS Monoclonals FITC is highly sensitive to pH extremes.
• Conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  TCR   alpha   beta   Receptor   Receptor   beta-1   Chain   Region   TRBC1   Receptor   alpha   Chain   Region   TRAC   TCRA  
• Gene symbol
  TRAC, TRA, TRBC1, NCOR2
• Short name
  TCR, alpha, beta (T Receptor, T- Receptor beta-1 Chain C Region, TRBC1, T- Receptor alpha Chain C Region, TRAC, TCRA) (FITC) Antibody
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, Fluorescein
• Label
  FITC
• Alternative name
  Anti-TCR, alpha, beta (T Cell Receptor, T-cell Receptor beta-1 Chain C Region, TRBC1, T-cell Receptor alpha Chain C Region, TRAC, TCRA) (FITC)
• Alternative technique
  antibodies, fluorescine
• Tissue
  cell, region

Gene info

• Identity
  HGNC:12029
• Gene
  TRAC
• Long gene name
  T cell receptor alpha constant
• GenBank acession
  • X02592
• Locus
  14q11.2
• Discovery year
  2000-05-08
• Entrez gene record
  28755
• Pubmed identfication
  • 3875483
  • 8188290
• RefSeq identity
  • NG_001332
• Classification
  • T cell receptor alpha locus at 14q11.2
• VEGA ID
  OTTHUMG00000028683

Gene info

• Identity
  HGNC:12027
• Gene
  TRA
• Long gene name
  T cell receptor alpha locus
• Synonyms gene
  • TCRA
  • TRA@
• Synonyms gene name
  • TCRA, TRA@
• Locus
  14q11.2
• Discovery year
  1986-01-01
• Entrez gene record
  6955
• Pubmed identfication
  • 3875152
  • 3875483
• RefSeq identity
  • NG_001332
• Classification
  • T cell receptor alpha locus at 14q11.2

Gene info

• Identity
  HGNC:12156
• Gene
  TRBC1
• Long gene name
  T cell receptor beta constant 1
• Synonyms
  • TCRBC1
  • BV05S1J2.2
• GenBank acession
  • M12887
• Locus
  7q34
• Discovery year
  2000-05-15
• Entrez gene record
  28639
• Pubmed identfication
  • 3860845
• RefSeq identity
  • NG_001333
• Classification
  • T cell receptor beta locus at 7q34
• VEGA ID
  OTTHUMG00000190609

Gene info

• Identity
  HGNC:7673
• Gene
  NCOR2
• Long gene name
  nuclear receptor corepressor 2
• Synonyms gene name
  • nuclear receptor co-repressor 2
• Synonyms
  • SMRT
  • SMRTE
  • TRAC-1
  • CTG26
  • TNRC14
• GenBank acession
  • U37146
• Locus
  12q24.31
• Discovery year
  1999-12-17
• Entrez gene record
  9612
• Pubmed identfication
  • 7566127
  • 8813722
• RefSeq identity
  • NM_006312
• Classification
  • Myb/SANT domain containing
  • NCoR/SMRT transcriptional repression complex subunits
• VEGA ID
  OTTHUMG00000150455

MeSH Data

• Name
  Cytophotometry
• Concept
  Scope note: A method for the study of certain organic compounds within cells, in situ, by measuring the light intensities of the selectively stained areas of cytoplasm. The compounds studied and their locations in the cells are made to fluoresce and are observed under a microscope.
• Tree numbers
  • E01.370.225.500.386
  • E05.196.712.516.600.240
  • E05.200.500.386
  • E05.242.386
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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