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Target antigen
HEF1
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB
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Immunogen
E.coli-derived human HEF1 recombinant protein (Position: K273-E421). Human HEF1 shares 83% amino acid (aa) sequence identity with mouse HEF1.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the HEF1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The HEF1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Enhancer of filamentation 1 (EF1), also known as NEDD-9, is a protein that in humans is encoded by the NEDD9 gene. The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. It is mapped to 6p24.2. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. NEDD9 is also a highly relevant cancer gene that governs metastatic potential in human melanoma. What’s more, it has been speculated that NEDD9 may be an important linking element between extracellular signaling and regulation of the cytoskeleton.
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Related articles
1. Law, S. F., Estojak, J., Wang, B., Mysliwiec, T., Kruh, G., Golemis, E. A. Human enhancer of filamentation 1, a novel p130(cas)-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Molec. Cell. Biol. 16: 3327-3337, 1996. 2. Gross, M. B. Personal Communication. Baltimore, Md. 9/4/2012.
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Gene Name
NEDD9
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Protein Name
Enhancer of filamentation 1
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Gene Full Name
neural precursor cell expressed, developmentally down-regulated 9
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Synonyms
CAS L antibody|Cas like docking antibody|Cas scaffolding protein family member 2 antibody|CAS-L antibody|CAS2 antibody|CASL antibody|CASL_HUMAN antibody|CASS2 antibody|Crk associated substrate related antibody|Crk associated substrate related protein antibody|CRK-associated substrate-related protein antibody|dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)) antibody|dJ49G10.2 antibody|dJ761I2.1 (enhancer of filamentation (HEF1)) antibody|dJ761I2.1 antibody|Enhancer of filamentation 1 antibody|Enhancer of filamentation 1 p55 antibody|HEF 1 antibody|HEF1 antibody|NEDD 9 antibody|NEDD-9 antibody|NEDD9 antibody|NEDD9 protein antibody|Neural cell expressed developmentally down regulated 9 antibody|Neural precursor cell expressed developmentally down regulated 9 antibody|Neural precursor cell expressed developmentally down-regulated protein 9 antibody|NY REN 12 antigen antibody|p105 antibody|Protein NEDD9 antibody|Renal carcinoma antigen NY-REN-12 antibody
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Uniprot ID
Q14511
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Entrez GeneID
4739
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
