Anti-TXK Antibody

• Catalog number
  A1203-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  TXK
• Target Alternative Name
  PTK4; RLK; Tyrosine-protein kinase TXK; Protein-tyrosine kinase 4; Resting lymphocyte kinase
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TXK
• Accession
  P42681
• Gene Id
  7294
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
• Purification
  Affinity purified
• Application
  WB, IH
• Positive Control
  WB: Jurkat, THP1, mouse spleen, rat spleen lysate; IHC: human placenta tissue section
• Application And Usages
  WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
• Description
  Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TXK  
• Gene symbol
  TXK
• Short name
  Anti-TXK Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibody toTXK (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  TXK tyrosine kinase, BTKL and PSCTK5 and PTK4 and RLK and TKL, TXK and IDBG-17234 and ENSG00000074966 and 7294, transferase activity, nuclei, Txk and IDBG-170081 and ENSMUSG00000054892 and 22165, TXK and IDBG-642080 and ENSBTAG00000005055 and 504782

Gene info

• Identity
  HGNC:12434
• Gene
  TXK
• Long gene name
  TXK tyrosine kinase
• Synonyms gene
  • PTK4
• Synonyms gene name
  • PTK4 protein tyrosine kinase 4
• Synonyms
  • TKL
  • PSCTK5
  • BTKL
  • RLK
• GenBank acession
  • L27071
• Locus
  4p12
• Discovery year
  1994-12-08
• Entrez gene record
  7294
• Pubmed identfication
  • 7951233
  • 7528718
• RefSeq identity
  • NM_003328
• Classification
  • Tec family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000102065

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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