CBL2 (Tyr700) Antibody, ALEXA FLUOR 488

• Catalog number
  bs-4072R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  CBL2 (Tyr700) Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-CBL2 Tyr700 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CBL2 Tyr700
• Specificity
  This is a highly specific antibody against CBL2 Tyr700.
• Modification
  Phosphorylation
• Modification Site
  Tyr700
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human C CBL around the phosphorylation site of Tyr700
• Gene ID Number
  867
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  C CBL Tyr700; CBL2 Tyr700; CBL2 Y700; p-CBL2 Tyr700; p-CBL2 Y700; C CBL; Cas-Br-M murine ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; CBL 2;E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; RGD1561386; RING finger protein 55; RNF55v Signal transduction protein CBL; 4732447J05Rik; CBL_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-CBL2 Tyr700 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  CBL2   Tyr700  
• Gene symbol
  CBL
• Short name
  Anti-CBL2 Tyr700
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  CBL2 (Tyr700) Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1541
• Gene
  CBL
• Long gene name
  Cbl proto-oncogene
• Synonyms gene
  • CBL2
• Synonyms gene name
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
• Synonyms
  • RNF55
  • c-Cbl
• Synonyms name
  • oncogene CBL2
• GenBank acession
  • X57110
• Locus
  11q23.3
• Discovery year
  1989-06-30
• Entrez gene record
  867
• Pubmed identfication
  • 2013228
• RefSeq identity
  • NM_005188
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000166170
• Locus Specific Databases
  • LRG_608

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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