RO5126766

• Catalog number
  B1705-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  RO5126766; Ro-5126766; Ro5126766; Ro 5126766; RO 5126766; RO-5126766; CH5126766; Ro 5126766; CH 5126766; CH-5126766; 3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one; 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one
• Description
  Ro5126766 (CH5126766) is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM, respectively.
• CAS Number
  946128-88-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₈FN₅O₅S
• Molecular Weight
  471.46
• Cell Permeable
  Yes
• Purity
  >98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective dual RAF/MEK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16719221
• PubChem CID Link
• SMILES
  CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
• InChi
  InChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27)
• InChi Key
  LMMJFBMMJUMSJS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RO5126766  
• Short name
  RO5126766
• Alternative name
  RO5126766

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