BAX Activator, BAM7

  • Catalog number
    2451-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7
  • Description
    A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.
  • CAS Number
    331244-89-4
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₁H₁₉N₅O₂S
  • Molecular Weight
    405.47
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (~ 2 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent and selective BAX activator
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • PubChem CID
    5754137
  • SMILES
    CCOC1=CC=CC=C1NN=C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C
  • InChi
    InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
  • InChi Key
    KOCVKGYKBLJEPK-LYBHJNIJSA-N
  • MSDS Available
    Yes
  • Gene target
    BAX   Activator   BAM7  
  • Gene symbol
    BAX
  • Short name
    BAX Activator, BAM7
  • Alternative name
    BCL2-associated X protein Activator, BAM7
  • Alternative to gene target
    BCL2-associated X protein, BCL2L4, BAX and IDBG-61459 and ENSG00000087088 and 581, BH3 domain binding, nuclei, Bax and IDBG-183241 and ENSMUSG00000003873 and 12028, BAX and IDBG-640344 and ENSBTAG00000013340 and 100850136,280730
Gene info
  • Identity
  • Gene
    BAX
  • Long gene name
    BCL2 associated X, apoptosis regulator
  • Synonyms gene name
    • BCL2-associated X protein
    • BCL2 associated X protein
  • Synonyms
  • Locus
  • Discovery year
    1994-11-08
  • Entrez gene record
    581
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • BCL2 family
  • VEGA ID
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