DNA methylation inhibitor, Dichlone

• Catalog number
  2860-500
• Price
  Please ask
• Size
  500 mg

• Alternative_name
  2,3-Dichloro-1,4-naphthoquinone, Dichlon
• Description
  Dichlone, a popular pesticide and fungicide, acts as a potent DNA methylation inhibitor (EC₅₀ = 460 nM against Dnmt3A/3L catalytic complex). Dichlone efficiently reactivates YFP gene expression in a stable HEK293 cell line by promoter demethylation.
• CAS Number
  117-80-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₀H₄Cl₂O₂
• Molecular Weight
  227.04
• Cell Permeable
  Yes
• Purity
  ≥95% by GC
• Solubilities
  DMSO or EtOH
• Handling
  Protect from air and light
• Tag Line
  A DNA methylation inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00001677
• PubChem CID
  8342
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl
• InChi
  InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H
• InChi Key
  SVPKNMBRVBMTLB-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
• Gene
  Non-methylated DNA at CpG islands organizes histone methylation through ZF-CxxC proteins in epigenetic biological systems. DNA and histone Methylation is catalyzed by enzymes; such methylation can be involved in hodyonr modification, regulation of gene expression, regulation of protein function, and RNA processing. Methylation of heavy metals can also occur outside biological systems. Chemical methylation of tissue samples is also one method for reducing certain histological staining artifacts. The counterpart of methylation is demethylation.

• Gene target
  DNA   methylation   inhibitor   Dichlone  
• Gene symbol
  PRKDC, HLA-DOA
• Short name
  DNA inhibitor, Dichlone
• Technique
  dna
• Alternative name
  Desoxyribonucleic acid methylation suppressor, Dichlone

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

Gene info

• Identity
  HGNC:4936
• Gene
  HLA-DOA
• Long gene name
  major histocompatibility complex, class II, DO alpha
• Synonyms gene
  • HLA-DZA
  • HLA-DNA
• Synonyms
  • HLA-D0-alpha
• GenBank acession
  • M31525
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3111
• Pubmed identfication
  • 2370084
• RefSeq identity
  • NM_002119
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031211
• Locus Specific Databases
  • IMGT/HLA Database

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