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Anti-MEK4 (Thr261) (Polyclonal), ALEXA Fluor 594

Anti-MEK4 (Thr261) (Polyclonal), ALEXA Fluor 594 is available 1 time from Bioss polyclonal antibodies labs

GENTObs-3693R-A594 | Anti-MEK4 (Thr261) (Polyclonal), ALEXA Fluor 594 size: 100 microliters | 600.11 USD

Catalog number GENTObs-3693R-A594
Price 600.11 USD
Size 100 microliters
1. Gene info
Identity 6844
Gene MAP2K4
Long gene name mitogen-activated protein kinase kinase 4
Synonyms gene
  • SERK1
Synonyms
  • MEK4
  • JNKK1
  • PRKMK4
  • MKK4
GenBank acession
  • L36870
Locus 17p12
Discovery year 1997-11-11
Entrez gene record 6416
Pubmed identfication
  • 7716521
Classification
  • Mitogen-activated protein kinase kinases
  • MicroRNA protein coding host genes
Havana BLAST/BLAT OTTHUMG00000178267
Product images
    Formalin-fixed and paraffin embedded rat skeletal muscle labeled with Anti Phospho-SEK1/MKK4 (Thr261) Polyclonal Antibody, Unconjugated (bs-3693R) at 1:200 followed by conjugation to the secondary antibody and DAB stainingFormalin-fixed and paraffin embedded rat lung labeled with Anti Phospho-SEK1/MKK4 (Thr261) Polyclonal Antibody, Unconjugated (bs-3693R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Type Conjugated Primary Antibody
Conjugated with ALEXA FLUOR® 594
Host organism Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide MEK4 Thr261
Specificity This antibody will cross react with MAP2K3 when phosphorylated at Thr222, MAP2K6 when phosphorylated at Thr211, and MAP2K7 when phosphorylated at Thr275.MEK4 (Thr261)
Modification Phosphorylation
Modification site Thr261
Clonality Polyclonal Antibody
Clone Polyclonal Antibodies
Concentration 1ug per 1ul
Subcellular locations Cytoplasm, Nucleus
Antigen Source KLH conjugated synthetic phosphopeptide derived from human MEK4 around the phosphorylation site of Thr261
Gene ID 6416
Swiss Prot P45985
Applications IF(IHC-P)
Applications with corresponding dilutions IF(IHC-P)(1:50-200)
Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Background information Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Purification method Purified by Protein A.
Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Excitation emission 590nm/617nm
Synonyms Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK; MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SERK1; SKK1
Also known as MEK4 (Thr261) Polyclonal Antibody
Other name Anti-MEK4 (Thr261) Polyclonal
Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Properties For facs or microscopy Alexa 1 conjugate.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Gene targetMEK4 Thr261
Short name Anti-MEK4 (Thr261)
Technique Polyclonal, anti
Isotype Immunoglobulin G (IgG)
Label ALEXA FLUOR 594
Alternative name MEK4 (Thr261) Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
Alternative technique polyclonals
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Anti-MEK4 (Thr261) | Technique alternative | 01011193349
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