Human CellExp™ MAG / Siglec-4a, Fc Tag, Human Recombinant
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Catalog number
P1481-10
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Price
Please ask
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Size
10 µg
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Synonyms
MAG, Siglec-4a, GMA, S-MAG
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Alternative_names
MAG, Siglec-4a, GMA, S-MAG
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Description
Adhesion molecule that mediates interactions between myelinating cells and neurons
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Recombinant
True
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Source
HEK 293 cells
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Purity by SDS PAGE
>95%
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Assay
SDS-PAGE
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Endotoxin Level
Less than 1.0 EU per ug by the LAL method.
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Molecular Weight
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81.1 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Storage Temp
-20ºC
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized powder
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Physical form description
Lyophilized
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Reconstitution Instructions
Reconstitute in sterile deionized water to the desired protein concentration.
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Background Information
Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.
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Amino acid sequence
Gly 20 - Pro 516
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
MAG, RETREG2, ERCC2
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Short name
CellExp™ MAG / Siglec-4a, Fc Tag, Recombinant
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Humans
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Alternative name
H. sapiens CellExp™ myelin associated glycoprotein / Siglec-4a, fragment c detection labelled, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
myelin associated glycoprotein, GMA and S-MAG and SIGLEC-4A and SIGLEC4A, MAG and IDBG-43939 and ENSG00000105695 and 4099, protein binding, Plasma membranes, Mag and IDBG-171670 and ENSMUSG00000036634 and 17136, BT.96871 and IDBG-635591 and ENSBTAG00000017044 and 540576
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Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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