MK-1439

  • Catalog number
    B1250-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine
  • Description
    MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively. It displays excellent activity of suppressing the replication of WT virus with 95% effective concentration of 20 nM. It also exhibited anti-virus activity against 10 different HIV-1 subtype viruses including K103N, Y81C.
  • CAS Number
    1338225-97-0
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₇H₁₁ClF₃N₅O₃
  • Molecular Weight
    425.75
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    58460047
  • SMILES
    CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
  • InChi
    InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
  • InChi Key
    ZIAOVIPSKUPPQW-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
    MK-1439  
  • Gene symbol
    MVK, STYXL1, MDK, MAPKAPK3, EPCAM
  • Short name
    MK-1439
  • Alternative name
    MK-1439
Gene info
Gene info
Gene info
Gene info
Gene info
Product images
Similar products
Filters
Contact
Chat with gentaur.com employee