MK-1439
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Catalog numberB1250-5
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PricePlease ask
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Size5 mg
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Alternative_name3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine
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DescriptionMK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and Y181C reverse transcriptase (RT) mutants, respectively. It displays excellent activity of suppressing the replication of WT virus with 95% effective concentration of 20 nM. It also exhibited anti-virus activity against 10 different HIV-1 subtype viruses including K103N, Y81C.
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CAS Number1338225-97-0
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₁ClF₃N₅O₃
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Molecular Weight425.75
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID58460047
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SMILESCN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
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InChiInChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
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InChi KeyZIAOVIPSKUPPQW-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolMVK, STYXL1, MDK, MAPKAPK3, EPCAM
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Short nameMK-1439
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Alternative nameMK-1439
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Gene info
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Identity
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Gene
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Long gene namemevalonate kinase
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Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameserine/threonine/tyrosine interacting like 1
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Synonyms gene
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Synonyms gene name
- dual specificity phosphatase 24 (putative)
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAP kinase phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemidkine
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Synonyms gene
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Synonyms gene name
- neurite growth-promoting factor 2
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Synonyms
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Locus
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Discovery year1991-07-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMAPK activated protein kinase 3
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Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-03-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAPK activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameepithelial cell adhesion molecule
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-10-02
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Entrez gene record
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Pubmed identfication
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Classification
- MicroRNA protein coding host genes
- CD molecules
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VEGA ID
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Locus Specific Databases