Bml-278 SIRT1 activator, SIRT1 activator
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Catalog number
SIH-349-5MG
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Price
Please ask
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Size
5 mg
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Stock availabilitIn Stock
In Stock
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CAS number
No Available. See included datasheet
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Description
SIRT1 activator
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Molecular weight
391,5 g/mol
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Primary research fields
Cell Signaling, Epigenetics
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Other name
N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C24H25NO4
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Origin
Synthetic
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Purity pourcentage
>98% (TLC), NMR conforms
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Soluble in
Soluble in 5 mg/ml DMSO
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Physical appearance
Off-White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
Refer to PubChem
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Scientific context
A structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.
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Bibliography
1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.
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Release date
1-Aug-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of BML-278 SIRT1 activator (SIH-349), a SIRT1 activator. CAS #: N/A. Molecular Formula: C24H25NO4. Molecular Weight: 391.5 g/mol. Chemical structure of BML-278 SIRT1 activator, a SIRT1 activator (SIH-349). CAS # N/A. Molecular Formula: C24H25NO4.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Gene target
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Gene symbol
SIRT1, SIRT1-AS
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Short name
Bml-278 SIRT1 activator, SIRT1 activator
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Alternative name
Bml-278 sirtuin 1 activator, sirtuin 1 activator
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Alternative to gene target
sirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629
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Gene info
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Identity
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Gene
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Long gene name
sirtuin 1
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Synonyms gene name
- sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
- sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2001-03-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
SIRT1 antisense RNA
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Locus
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Discovery year
2015-09-23
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Entrez gene record
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Pubmed identfication
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Classification
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