Human CellExp™ LRRC4 /NGL-2, human recombinant

  • Catalog number
    7461-10
  • Price
    Please ask
  • Size
    10 ug
  • Synonyms
    LRRC4, NGL-2, BAG, NAG14.
  • Alternative_names
    LRRC4, NGL-2, BAG, NAG14.
  • Description
    Regulates the formation of excitatory synapses through the recruitment of pre-and-postsynaptic proteins
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    ≥92%
  • Assay
    SDS-PAGE
  • Biological activity
    Measured by its binding ability in a functional ELISA. Immobilized Recombinant mouse Netrin-G2a Fc chimera at 4 ug/ml, can bind rhLRRC4 with an apparent KD < 10 nM.
  • Results
    Measured by its binding ability in a functional ELISA. Immobilized Recombinant mouse Netrin-G2a Fc chimera at 4 ug/ml, can bind rhLRRC4 with an apparent KD < 10 nM.
  • Molecular Weight
    This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 55.6 kDa. The predicted N-terminus is Ala 39. DTT-reduced Protein migrates as 90-110 kDa due to glycosylation.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
  • Background Information
    LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4 / NGL-2 specifically expressed in brain. LRRC4 / NGL-2 regulates the formation of excitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4 / NGL-2 plays an important role for auditory synaptic responses and involved in the suppression of glioma.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    LRRC4, ERBB2, LRRC4C, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2
  • Short name
    CellExp™ LRRC4 /NGL-2, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ LRRC4 /NGL-2, H. sapiens Rec.
  • Alternative technique
    rec
Gene info
  • Identity
  • Gene
  • Long gene name
    leucine rich repeat containing 4
  • Synonyms gene name
    • leucine-rich repeat-containing 4
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-01
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Ig-like cell adhesion molecule family
    • I-set domain containing
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
Filters
Contact
Chat with gentaur.com employee