LY-333,531 hydrochloride

Alternative_name

Ruboxistaurin
Description

An isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC₅₀ = 4.7 nM) and PKCβII (IC₅₀ = 5.9 nM) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCβI and PKCβII over PKCα.
CAS Number

169939-93-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₂₉ClN₄O₃
Molecular Weight

505.01
Cell Permeable

Yes
Purity

≥98% by NMR
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A protein kinase Cβ inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
MDL Number

MFCD08702685
PubChem CID

9870785
PubChem CID Link
SMILES

CN(C)CC1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl
InChi

InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
InChi Key

NYQIEYDJYFVLPO-FERBBOLQSA-N
Data Sheet Link
MSDS Available

Yes