H-89 Dihydrochloride

Alternative_name

N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride
Description

A cell-permeable, ATP-competitive inhibitor of Protein Kinase A (PKA) (IC₅₀ = 50 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII with IC₅₀ values of 120 nM, 80 nM and 270 nM respectively.
CAS Number

127243-85-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₀BrN₃O₂S.2HCl
Molecular Weight

519.28
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (200 mg/ml) and H₂O (25 mg/ml)
Handling

Protect from air and light
Tag Line

A protein kinase A (PKA) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD11045926
PubChem CID

5702541
PubChem CID Link
SMILES

C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br.Cl.Cl
InChi

InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;
InChi Key

GELOGQJVGPIKAM-WTVBWJGASA-N
Data Sheet Link
MSDS Available

Yes

Gene target

H-89 Dihydrochloride
Gene symbol

NCAPH, LINC01833, HLA-H, IGHV3-69-1, FUT1, PIGH, NEFH, ATCAY, RAB11B, RAB35
Short name

H-89 Dihydrochloride
Alternative name

H-89 Dihydrochloride

Identity

HGNC:1112
Gene

NCAPH
Long gene name

non-SMC condensin I complex subunit H
Synonyms gene
- BRRN1
Synonyms gene name
- barren (Drosophila) homolog
- barren homolog (Drosophila)
- barren homolog 1 (Drosophila)
- non-SMC condensin I complex, subunit H
Synonyms
- CAP-H
- hCAP-H
GenBank acession
- BC024211
Locus

2q11.2
Discovery year

1998-02-11
Entrez gene record

23397
Pubmed identfication
- 9417923
RefSeq identity
- NM_015341
Classification
- Condensin I subunits
- Kleisins
VEGA ID

OTTHUMG00000130451

Identity

HGNC:5631
Gene

IGHV3-69-1
Long gene name

immunoglobulin heavy variable 3-69-1 (pseudogene)
Synonyms gene
- IGHV3-H
Synonyms gene name
- immunoglobulin heavy variable 3-H (provisional)
- immunoglobulin heavy variable 3-H pseudogene (provisional)
- immunoglobulin heavy variable 3-H (pseudogene)
Synonyms
- IGHV3-h
GenBank acession
- AJ879484
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28402
Pubmed identfication
- 16133446
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000191145

Identity

HGNC:4012
Gene

FUT1
Long gene name

fucosyltransferase 1 (H blood group)
Synonyms gene
- H
- HSC
Synonyms gene name
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included)
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
Synonyms name
- galactoside 2-alpha-L-fucosyltransferase
Locus

19q13.33
Discovery year

1989-06-06
Entrez gene record

2523
RefSeq identity
- NM_000148
Classification
- Fucosyltransferases
- Blood group antigens
VEGA ID

OTTHUMG00000183325
Locus Specific Databases
- Blood Group Antigen Mutation Database
- LRG_810

Identity

HGNC:7737
Gene

NEFH
Long gene name

neurofilament heavy chain
Synonyms gene name
- neurofilament, heavy polypeptide 200kDa
- neurofilament heavy polypeptide
- neurofilament heavy
Synonyms
- NF-H
- NFH
Locus

22q12.2
Discovery year

1988-08-31
Entrez gene record

4744
RefSeq identity
- NM_021076
Classification
- Intermediate filaments Type IV
VEGA ID

OTTHUMG00000151155
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database