Nigericin sodium salt
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Catalog number2096-5
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PricePlease ask
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Size5 mg
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Alternative_nameAntibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A; BRN 169675
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DescriptionNigericin is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K⁺> Rb⁺ Cs⁺>> Na⁺. Also activates NLRP3/NALP3 and signals through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release.
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CAS Number28643-80-3
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Structure AvailableYes
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Molecular FormulaC₄₀H₆₇NaO₁₁
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Molecular Weight746.94
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Cell PermeableNo
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Purity≥98% by TLC
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SolubilitiesDMSO (~50 mg/ml) or Ethanol (~20 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA polyether ionophore
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD00036825
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PubChem CID16760591
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SMILESCC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
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InChiInChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
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InChi KeyMOYOTUKECQMGHE-PDEFJWSRSA-M
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MSDS AvailableYes
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Gene target
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Short nameNigericin sodium salt
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Alternative nameNigericin sodium salt
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