Nigericin sodium salt

• Catalog number
  2096-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A; BRN 169675
• Description
  Nigericin is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K⁺> Rb⁺ Cs⁺>> Na⁺. Also activates NLRP3/NALP3 and signals through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release.
• CAS Number
  28643-80-3
• Structure Available
  Yes
• Molecular Formula
  C₄₀H₆₇NaO₁₁
• Molecular Weight
  746.94
• Cell Permeable
  No
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~50 mg/ml) or Ethanol (~20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A polyether ionophore
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• MDL Number
  MFCD00036825
• PubChem CID
  16760591
• PubChem CID Link
• SMILES
  CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
• InChi
  InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
• InChi Key
  MOYOTUKECQMGHE-PDEFJWSRSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Nigericin   sodium   salt  
• Short name
  Nigericin sodium salt
• Alternative name
  Nigericin sodium salt

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