Bay 61-3606 Hydrochloride

• Catalog number
  1796-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
• Description
  Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.
• CAS Number
  732983-37-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₈N₆O₃.HCl
• Molecular Weight
  426.86
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  H₂O (30 mg/ml) DMSO (2 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A Syk inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• PubChem CID
  52949496
• PubChem CID Link
• SMILES
  COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl
• InChi
  InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
• InChi Key
  HLYFDKZWVIBYKL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Bay   61-3606   Hydrochloride  
• Gene symbol
  IGHV4-61, SNORA81, IGLV8-61, RNU6-61P, MIR3606, SCARNA2, SH3GLB1
• Short name
  Bay 61-3606 Hydrochloride
• Alternative name
  Bay 61-3606 Hydrochloride

Gene info

• Identity
  HGNC:5655
• Gene
  IGHV4-61
• Long gene name
  immunoglobulin heavy variable 4-61
• GenBank acession
  • M29811
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28391
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151976

Gene info

• Identity
  HGNC:32667
• Gene
  SNORA81
• Long gene name
  small nucleolar RNA, H/ACA box 81
• Synonyms
  • HBI-61
• GenBank acession
  • AM055745
• Locus
  3q27.3
• Discovery year
  2006-04-04
• Entrez gene record
  677847
• Pubmed identfication
  • 15199136
  • 16381836
  • 16361266
• RefSeq identity
  • NR_002989
• Classification
  • Small nucleolar RNAs, H/ACA box

Gene info

• Identity
  HGNC:5931
• Gene
  IGLV8-61
• Long gene name
  immunoglobulin lambda variable 8-61
• GenBank acession
  • Z73650
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28774
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000150844

Gene info

• Identity
  HGNC:42551
• Gene
  RNU6-61P
• Long gene name
  RNA, U6 small nuclear 61, pseudogene
• Synonyms gene
  • RNU6-61
• Synonyms gene name
  • RNA, U6 small nuclear 61
• Locus
  13q31.1
• Discovery year
  2011-08-08
• Entrez gene record
  106480435

Gene info

• Identity
  HGNC:38881
• Gene
  MIR3606
• Long gene name
  microRNA 3606
• Synonyms
  • hsa-mir-3606
• Locus
  2q32.2
• Discovery year
  2010-09-15
• Entrez gene record
  100500837
• RefSeq identity
  • NR_037401
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:32558
• Gene
  SCARNA2
• Long gene name
  small Cajal body-specific RNA 2
• Synonyms
  • mgU2-25/61
  • HBII-382
• GenBank acession
  • BK005568
• Locus
  1q13.1
• Discovery year
  2006-03-31
• Entrez gene record
  677766
• Pubmed identfication
  • 15556860
• RefSeq identity
  • NR_003023
• Classification
  • Small Cajal body-specific RNAs
• VEGA ID
  OTTHUMG00000184013

Gene info

• Identity
  HGNC:10833
• Gene
  SH3GLB1
• Long gene name
  SH3 domain containing GRB2 like, endophilin B1
• Synonyms gene name
  • SH3-domain, GRB2-like, endophilin B1
• Synonyms
  • CGI-61
  • KIAA0491
  • Bif-1
  • PPP1R70
• Synonyms name
  • protein phosphatase 1, regulatory subunit 70
• GenBank acession
  • AF263293
• Locus
  1p22.3
• Discovery year
  2000-07-31
• Entrez gene record
  51100
• Pubmed identfication
  • 11161816
  • 11259440
• RefSeq identity
  • NM_016009
• Classification
  • N-BAR domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000010257

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