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anti-5-hmC polyclonal antibody (rabbit)

anti-5-hmC polyclonal antibody (rabbit) is available 1 time from Biovision labs

6830-50 | anti-5-hmC polyclonal antibody (rabbit) size: 5-hmC polyclonal antibody (rabbit) | 384.00 USD

Catalog number 6830-50
Supplier Biovision
Price 384.00 USD
Size 5-hmC polyclonal antibody (rabbit)
1. Gene info
Identity 24446
Gene HMCES
Long gene name 5-hydroxymethylcytosine binding, ES cell specific
Synonyms gene
  • C3orf37
Synonyms gene name
  • chromosome 3 open reading frame 37
  • 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
Synonyms
  • DC12
  • SRAPD1
Synonyms name
  • SOS response associated peptidase domain containing 1
  • embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
GenBank acession
  • AF201934
Locus 3q21.3
Discovery year 2006-01-02
Entrez gene record 56941
Pubmed identfication
  • 23434322
  • 23945014
RefSeq identity
  • NM_020187
Havana BLAST/BLAT OTTHUMG00000159452
Product images
    #0#.jpeg
Target of this antibody: 5-hmC
Alternative names of antibody target: 5-hydroxymethylcytosine
Background information: 5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. This results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC bases have been identified in Purkinje neurons, in granule cells and embryonic stem cells where they are present at high levels (up to 0.6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is abundant in brain tissue, especially in areas that are associated with higher cognitive functions. Preliminary results indicate that 5-hmC may have important roles distinct from 5-mC. Although its precise role has still to be shown, early evidence suggests a few putative mechanisms that could have big implications in epigenetics: 5-hydroxymethylcytosine may well represent a new pathway to demethylate DNA involving a repair mechanism converting 5-hmC to cytosine and, as such open up entirely new perspectives in epigenetic studies Due to the structural similarity between 5-mC and 5-hmC, these bases are experimentally almost indistinguishable. Recent articles demonstrated that the most common approaches (e.g. enzymatic approaches, bisulfite sequencing) do not account for 5-hmC. The development of the affinity-based technologies appears to be the most powerful way to differentially and specifically enrich 5-mC and 5-hmC sequences. The results shown here illustrate the use of this unique rabbit polyclonal antibody against 5-hydroxymethylcytosine that has been fully validated in various technologies.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
Clone: N/A
This antibody reacts with: Human, mouse, wide range.
Immunogene sequence: Polyclonal antibody raised in rabbit against 5-hydroxymethylcytosine conjugated to KLH.
Concentration of antibody: N/A
Form of antibody: Liquid
Formulation of this antibody: In PBS with 0.05% (W/V) sodium azide.
Purification method: Whole Anti-Sera
This antibody has been succesfully tested for use in following methods: ELISA, hmEdIP, Dot blot.
Recommended usage: hMeDIP: 2.5 µg/IP, Dot Blot: 1:200, ELISA: 1:500.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by Biovision. Rabbit antibodies are very stable and can be stored for several days at room temperature. Biovision adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name Oryctolagus cuniculus
French translation anticorps
Gene target5-hmC
Short name anti-5-hmC polyclonal antibody (rabbit)
Technique Polyclonal, Antibody, Rabbit, anti
Host Rabbit
Alternative name antibody to-5-hmC polyclonal (Antibody to) (production species: rabbit)
Alternative technique polyclonals
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