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Cathepsin Inhibitor

Cathepsin Inhibitor is available 2 times from Biovision labs

1982-1 | Cathepsin G Inhibitor size: 1 mg | 249.20 USD

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K162-100 | Cathepsin G Inhibitor Screening Kit (Colorimetric) size: 100 assays | 656.26 USD

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CAS Number 429676-93-7
Structure Available? Yes
Salt Form No
Molecular Formula C₃₆H₃₃N₂O₆P
Molecular Weight 620.63
Cell-Permeable? No
Purity ≥98% by HPLC
Solubilities DMSO
Handling Protect from light and mositure
Tag Line A potent Cathepsin G inhibitor
Storage Condition -20°C
Shipping Condition gel pack
Shelf Life 60 months
MDL Number MFCD00130750
PubChem CID 9830518
SMILES CN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6= CC=CC=C65)P(=O)(O)O
InChi InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25) 36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42, 43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3, (H2,42,43,44)
InChi Key GNOZQRKYZJSIPZ-UHFFFAOYSA-N
MSDS Available Yes
Summary • Detection method- Absorbance (OD 405 nm) • Applications- Screen/study/characterize potential inhibitors of Cathepsin G
Detection Method Absorbance (OD 405 nm)
Applications Screen/study/characterize potential inhibitors of Cathepsin G
Features & Benefits • Convenient & Rapid • High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin G • Cathepsin G inhibitor is included in the kit
Storage Conditions -20°C
Shipping Conditions gel pack
Shelf life 12 months
Background Cathepsin G (CTSG, EC 3.4.21.20) is a Serine protease found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. BioVision’s Cathepsin G Inhibitor Screening Kit utilizes the ability of active Cathepsin G to cleave a synthetic pNA (4-Nitroaniline)-based peptide substrate to release pNA, which can be easily quantified using a colorimetric microplate reader. In the presence of a Cathepsin G inhibitor, the cleavage of this substrate is reduced/abolished resulting in decrease or total loss of the pNA absorbance. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize potential inhibitors of Cathepsin G.
Technique colorimetric
Alternative technique assays
Alternative to gene target v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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