ALDH2 Antibody (Center)

• Catalog number
  6748-100
• Price
  Please ask
• Size
  100 μl

• Antibody Target
  ALDH2
• Target Alternative Name
  ALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI.
• Antibody Type
  Polyclonal
• Species Reactivities
  Human. Predicted cross reactivity with mouse and rat samples.
• Immunogen Sequence
  This ALDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the Central region of human ALDH2.
• Accession
  P05091
• Gene Id
  217
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  100 µl of antibody in PBS with 0.09% (W/V) sodium azide
• Purification
  This antibody is purified through a protein A column, followed by peptide affinity purification.
• Application
  Western blot, IHC.
• Positive Control
  Western blot: A549 cell lysates and mouse liver and lung and rat liver tissue lysates, IHC: Human hepatocarcinoma.
• Application And Usages
  Western blot: ~1:1000, IHC: ~1:10-1:50.
• Description
  ALDH2 (Aldehyde dehydrogenase 2 family) belongs to the aldehyde dehydrogenase family which catalyze the chemical transformation from acetaldehyde to acetic acid and is the second enzyme of the major oxidative pathway of alcohol metabolism. Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ALDH2   Center  
• Gene symbol
  ALDH2
• Short name
  ALDH2 Antibody (Center)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  aldehyde dehydrogenase 2 family (mitochondrial) (antibody to-) (central)
• Alternative technique
  antibodies
• Alternative to gene target
  aldehyde dehydrogenase 2 family (mitochondrial), ALDH-E2 and ALDHI and ALDM, ALDH2 and IDBG-57710 and ENSG00000111275 and 217, oxidoreductase activity, multiple

Gene info

• Identity
  HGNC:404
• Gene
  ALDH2
• Long gene name
  aldehyde dehydrogenase 2 family member
• Synonyms gene name
  • aldehyde dehydrogenase 2 family (mitochondrial)
• GenBank acession
  • M26760
• Locus
  12q24.12
• Discovery year
  1986-01-01
• Entrez gene record
  217
• Pubmed identfication
  • 4015823
  • 2987944
• RefSeq identity
  • NM_000690
• Classification
  • Aldehyde dehydrogenases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000169603
• Locus Specific Databases
  • Human Polymorphisms of ALDH Genes

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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