Phytosphingosine

Alternative_name

4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
Description

Phytosphingosine is a phospholipid structurally similar to Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities.
CAS Number

554-62-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₈H₃₉NO₃
Molecular Weight

317.51
Cell Permeable

Yes
Purity

≥98% by TLC
Solubilities

EtOH (~ 2 mg/ml)
Handling

Protect from air and moisture
Tag Line

An apoptosis inducer
Storage Condition

-20 ̊C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD06804643
PubChem CID

122121
PubChem CID Link
SMILES

CCCCCCCCCCCCCCC(C(C(CO)N)O)O
InChi

InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChi Key

AERBNCYCJBRYDG-KSZLIROESA-N
Data Sheet Link
MSDS Available

Yes