Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AVP Receptor V3
This is a highly specific antibody against AVPR1B/AVP Receptor V3.
Antidiuretic hormone receptor 1b; Arginine vasopressin receptor 1B; Arginine vasopressin receptor 3; AVPR V1b; AVPR V3; Avpr1b; AVPR3; Pituitary vasopressin receptor 3; V1bR; V1BR_HUMAN; Vasopressin V1b receptor; Vasopressin V3 receptor; VPR3.
Purified by Protein A.
Human, Mouse, Rat
Background of the antigen
Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality (1-3). AVP mediates its effects through a family of G-protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b) (1,2). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion (3). It is detected as a full length protein and a shorter protein, which results from proteolytic cleavage of its amino terminus (4). The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration (3). The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney (5,6). Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP (5,7). The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system (7). The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores (8). AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors (2).
1ug per 1ul
AVPR1B/AVP Receptor V3
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
AVPR1B/AVP Receptor V3 Antibody,
Alternative to gene target
arginine vasopressin, ADH and ARVP and AVP-NPII and AVRP and VP, AVP and IDBG-45432 and ENSG00000101200 and 551, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, Extracellular, Avp and IDBG-206576 and ENSMUSG00000037727 and 11998, AVP and IDBG-640134 and ENSBTAG00000008027 and 280728, arginine vasopressin receptor 1B, AVPR3, AVPR1B and IDBG-106206 and ENSG00000198049 and 553, protein kinase C binding, Plasma membranes, Avpr1b and IDBG-191336 and ENSMUSG00000026432 and 26361, AVPR1B and IDBG-628969 and ENSBTAG00000017301 and 282861