Smo Antagonist, SA1
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Catalog number2154-2
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PricePlease ask
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Size2 mg
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Alternative_name3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
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DescriptionA Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₆H₂₉FN₄O₂
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Molecular Weight448.53
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Cell PermeableYes
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Purity≥95% by NMR
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SolubilitiesDMSO
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HandlingProtect from air and moisture
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Tag LineA Smoothened (Smo) antagonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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PubChem CID5308963
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SMILESCC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
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InChiInChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
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InChi KeyUTURPAUEBUIDJO-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionThe antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.
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Gene target
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Gene symbolSTAG1
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Short nameSmo Antagonist, SA1
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Alternative namesmoothened, frizzled family receptor Antagonist, SA1
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Alternative to gene targetsmoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308
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Gene info
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Identity
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Gene
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Long gene namestromal antigen 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-04-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
- Cohesin complex
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VEGA ID