Smo Antagonist, SA1

Alternative_name

3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Description

A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₉FN₄O₂
Molecular Weight

448.53
Cell Permeable

Yes
Purity

≥95% by NMR
Solubilities

DMSO
Handling

Protect from air and moisture
Tag Line

A Smoothened (Smo) antagonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
PubChem CID

5308963
PubChem CID Link
SMILES

CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi

InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key

UTURPAUEBUIDJO-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes
Additional description

The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

Gene target

Smo Antagonist SA1
Gene symbol

STAG1
Short name

Smo Antagonist, SA1
Alternative name

smoothened, frizzled family receptor Antagonist, SA1
Alternative to gene target

smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308