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Human Recombinant HSP60 Protein

Human Recombinant HSP60 Protein is available 3 times from Stressmark proteins labs

SPR-104C | Human Recombinant HSP60 Protein size: 2x100 µg | 647.79 USD

Catalog number SPR-104C
Price 647.79 USD
Size 2x100 µg
Net weight (g) 0.2
1. Gene info
Identity 5261
Gene HSPD1
Long gene name heat shock protein family D (Hsp60) member 1
Synonyms gene
  • SPG13
Synonyms gene name
  • heat shock 60kD protein 1 (chaperonin)
  • spastic paraplegia 13 (autosomal dominant)
  • heat shock 60kDa protein 1 (chaperonin)
  • GroEL
  • HSP60
GenBank acession
  • M34664
Locus 2q33.1
Discovery year 1991-07-19
Entrez gene record 3329
Pubmed identfication
  • 1980192
  • 11898127
RefSeq identity
  • NM_002156
  • Chaperonins
Havana BLAST/BLAT OTTHUMG00000154463
2. Gene info
Identity 35136
Gene HSPD1P18
Long gene name heat shock protein family D (Hsp60) member 1 pseudogene 18
Synonyms gene name
  • heat shock 60kDa protein 1 (chaperonin) pseudogene 18
Locus 5q31.1
Discovery year 2008-09-22
Entrez gene record 100359397
RefSeq identity
  • NG_016481
Havana BLAST/BLAT OTTHUMG00000163218
Product images

SPR-104A | Human Recombinant HSP60 Protein size: 50 µg | 252.55 USD


SPR-104B | Human Recombinant HSP60 Protein size: 100 µg | 434.88 USD

Stock availability In Stock
Scientific context In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the best characterized chaperones. HSP60, also known as Cpn60 or GroEl, is an abundant protein synthesized constitutively in the cell that is induced to a higher concentration after brief cell shock. It is present in many species and exhibits a remarkable sequence homology among various counterparts in bacteria, plants, and mammals with more than half of the residues identical between bacterial and mammalian HSP60 (1-3). Whereas mammalian HSP60 is localized within the mitochondria, plant HSP60, or otherwise known as Rubisco-binding protein, is located in plant chloroplasts. It has been indicated that these proteins carry out a very important biological function due to the fact that HSP60 is present in so many different species. The common characteristics of the HSP60s from the divergent species are i) high abundance, ii) induction with environmental stress such as heat shock, iii) homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP, iv) ATPase activity and v) a role in folding and assembly of oligomeric protein structures (4). These similarities are supported by recent studies where the single-ring human mitochondrial homolog, HSP60 with its co-chaperonin, HSP10 were expressed in a E. coli strain, engineered so that the groE operon is under strict regulatory control. This study has demonstrated that expression of HSP60-HSP10 was able to carry out all essential in vivo functions of GroEL and its co-chaperonin, GroES (5). Another important function of HSP60 and HSP10 is their protective functions against infection and cellular stress. HSP60 has however been linked to a number of autoimmune diseases, as well as Alzheimer's, coronary artery diseases, MS, and diabetes (6-9).
Protein target HSP60
Protein reactivity Human
Certificate of analysis This product has been certified >90% pure using SDS-PAGE analysis. The protein has ATPase activity at the time of manufacture of 3.6µM phosphate liberated/hr/µg protein in a 200µl reaction at 37°C (pH7.5) in the presence of 20ul of 1mM ATP using a Malachite Green assay.
Protein description Active Human Recombinant HSP60 Protein
Other name 60kDa chaperonin Protein, cb863 Protein, CPN60 Protein, GROEL Protein, GroEL Homolog Protein, HLD4 Protein, HSP65 Protein, HSPD1 Protein, HuCHA60 Protein, SPG13 Protein
Primary research area Cancer, Heat Shock
Category Protein
Brand name none
Origin Recombinant
NCBI number BC003030
Gene number 3329
Protein number P10809
Verified applications WB, SDS-PAGE, ATPase Activity Assay, Functional Assay, ELISA
Relevant bio activity ATPase active
Protein expression model E. coli
Protein charasterics See included datasheet.
Peptide sequence See included datasheet.
Protein purification Affinity Purified
Purity pourcentage >90% High purity
Recommended buffer for storage 20mM Phosphate Buffer, 150mM NaCl, 10% glycerol
Protein concentration Lot/batch specific. See included datasheet.
Protein specificity ~60 kDa
Protein tag His tag
Storage recommendations -20°C
Shipping recommendations Blue Ice or 4°C
Supplementary useful information Please see included datasheet or contact us
Protein cell localization Mitochondrion Matrix
Bibliography 1. Hartl F.U. (1996) Nature. 381: 571-579. 2. Bukau B. and Horwich A.L. (1998) Cell. 92: 351-366. 3.Hartl F.U. and Hayer-Hartl M. (2002) Science. 295: 1852-1858. 4. Jindal S., et al. (1989) Molecular and Cellular Biol. 9: 2279-2283. 5. La Verda D., et al (1999) Infect Dis. Obstet. Gynecol. 7: 64-71. 6. Itoh H., et al. (2002) Eur. J. Biochem. 269: 5931-5938. 7.Gupta S. and Knowlton A.A. J. Cell Mol Med. 9: 51-58. 8. Deocaris C.C. et al. (2006) Cell Stress Chaperones. 11: 116-128. 9. Lai H.C., et al. (2007) Am. J. Physiol. Endocrinol. Metab. 292: E292-E297.
Release date 1-Sep-2007
PubMed number 23775284, 24066722, 21506099
Tested applications Functional Assay, Western Blot Control, ELISA
Tested species reactivity Human
Representative figure legend SDS-PAGE of 60kDa Hsp60 protein (SPR-104). SDS-Page of human HSP60 Protein (SPR-104)
Warnings Non-hazardous materials
Protein origin Canada
Total weight (kg) 1.4
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Source Recombinants or rec. proteins
Group recombinants
Gene targetHSP60 Protein
Short name Recombinant HSP60 Protein
Technique Recombinant
Species Human
Alternative name H. sapiens recombinant HSP60 Protein
Alternative technique rec
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Recombinant HSP60 Protein | Technique alternative | 01012512
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • HSP60
  • Protein
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