MI-3 (Menin-MLL Inhibitor)

• Catalog number
  MBS577798
• Price
  Please ask
• Size
  2 mg

• Other size
  please contact us to order other different size
• Description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  MI-3   Menin-MLL   Inhibitor  
• Gene symbol
  KMT2A, MITF, CHD4, MIER1, CHD3, MIR1302-3, MIR509-3, MIR7-3, PIRC14
• Short name
  MI-3 (Menin-MLL Inhibitor)
• Alternative name
  MI-3 (Menin-myeloid/lymphoid and mixed-lineage leukemia (trithorax homolog, Drosophila) suppressor)
• Alternative to gene target
  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), ALL-1 and CXXC7 and HRX and HTRX1 and MLL and MLL/GAS7 and MLL1 and MLL1A and TET1-MLL and TRX1 and WDSTS, MLL and IDBG-73725 and ENSG00000118058 and 4297, lysine-acetylated histone binding, nuclei, Mll1 and IDBG-158453 and ENSMUSG00000002028 and 214162, MLL and IDBG-631302 and ENSBTAG00000018093 and 508330

Gene info

• Identity
  HGNC:7132
• Gene
  KMT2A
• Long gene name
  lysine methyltransferase 2A
• Synonyms gene
  • MLL
• Synonyms gene name
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
  • lysine (K)-specific methyltransferase 2A
• Synonyms
  • TRX1
  • HRX
  • ALL-1
  • HTRX1
  • CXXC7
  • MLL1A
• Synonyms name
  • Histone-lysine N-methyltransferase 2A
• GenBank acession
  • L04284
• Locus
  11q23.3
• Discovery year
  1991-11-15
• Entrez gene record
  4297
• Pubmed identfication
  • 1720549
• RefSeq identity
  • NM_005933
• Classification
  • PHD finger proteins
  • SET domain containing
  • Lysine methyltransferases
  • Zinc fingers CXXC-type
  • Bromodomain containing
• VEGA ID
  OTTHUMG00000166337
• Locus Specific Databases
  • LRG_613

Gene info

• Identity
  HGNC:7105
• Gene
  MITF
• Long gene name
  melanocyte inducing transcription factor
• Synonyms gene
  • WS2A
  • WS2
• Synonyms gene name
  • Waardenburg syndrome, type 2A
  • microphthalmia-associated transcription factor
  • melanogenesis associated transcription factor
• Synonyms
  • MI
  • bHLHe32
• Synonyms name
  • homolog of mouse microphthalmia
• Locus
  3p13
• Discovery year
  1993-10-27
• Entrez gene record
  4286
• Pubmed identfication
  • 8069297
  • 7874167
  • 7951321
• RefSeq identity
  • NM_198159
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000149921
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_776

Gene info

• Identity
  HGNC:1919
• Gene
  CHD4
• Long gene name
  chromodomain helicase DNA binding protein 4
• Synonyms
  • Mi-2b
  • Mi2-BETA
• GenBank acession
  • X86691
• Locus
  12p13.31
• Discovery year
  1998-03-20
• Entrez gene record
  1108
• Pubmed identfication
  • 7575689
  • 27235397
• RefSeq identity
  • NM_001273
• Classification
  • NuRD complex subunits
  • PHD finger proteins
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000169164

Gene info

• Identity
  HGNC:29657
• Gene
  MIER1
• Long gene name
  MIER1 transcriptional regulator
• Synonyms gene name
  • mesoderm induction early response 1 homolog (Xenopus laevis)
  • mesoderm induction early response 1, transcriptional regulator
• Synonyms
  • hMI-ER1
  • MI-ER1
  • KIAA1610
• Locus
  1p31.3
• Discovery year
  2005-07-14
• Entrez gene record
  57708
• Pubmed identfication
  • 12242014
  • 12482978
• RefSeq identity
  • NM_020948
• Classification
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000009194

Gene info

• Identity
  HGNC:1918
• Gene
  CHD3
• Long gene name
  chromodomain helicase DNA binding protein 3
• Synonyms
  • Mi-2a
  • ZFH
  • Mi2-ALPHA
• GenBank acession
  • U08379
• Locus
  17p13.1
• Discovery year
  1998-03-20
• Entrez gene record
  1107
• Pubmed identfication
  • 9326634
  • 7560064
• RefSeq identity
  • NM_001005273
• Classification
  • Small nucleolar RNA protein coding host genes
  • NuRD complex subunits
  • PHD finger proteins
• VEGA ID
  OTTHUMG00000150427

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37518
• Gene
  PIRC14
• Long gene name
  piwi-interacting RNA cluster 14
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313784
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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