SMAD6 Antibody

• Catalog number
  R31817
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SMAD6
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the SMAD6 antibody should be determined by the researcher.
• Intented use
  This SMAD6 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O43541
• Purity
  Antigen affinity
• Description
  Mothers against decapentaplegic homolog 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. It belongs to the SMAD family of proteins, which belongs to the TGF? superfamily of modulators. By PCR screening of a somatic cell hybrid panel and YACs, this gene was mapped to 15q22.31. And this gene acts as a mediator of TGF-beta and BMP antiflammatory activity. It can suppress 1L 1R-TLR signaling through its direct interaction with PEL1 and prevent NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. SMAD6 may play a role in blocking the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding and binding to regulatory elements in target promoter regions.
• Immunogen
  Amino acids 131-456 of human SMAD6 were used as the immunogen for the SMAD6 antibody.
• Storage
  After reconstitution, the SMAD6 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SMAD6  
• Gene symbol
  SMAD6
• Short name
  Anti-SMAD6
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to SMAD6
• Alternative technique
  antibodies
• Alternative to gene target
  SMAD family member 6, AOVD2 and HsT17432 and MADH6 and MADH7, SMAD6 and IDBG-18304 and ENSG00000137834 and 4091, transforming growth factor beta receptor, nuclei, Smad6 and IDBG-175757 and ENSMUSG00000036867 and 17130, SMAD6 and IDBG-645465 and ENSBTAG00000000625 and 511279

Gene info

• Identity
  HGNC:6772
• Gene
  SMAD6
• Long gene name
  SMAD family member 6
• Synonyms gene
  • MADH7
  • MADH6
• Synonyms gene name
  • MAD, mothers against decapentaplegic homolog 6 (Drosophila)
  • SMAD, mothers against DPP homolog 6 (Drosophila)
• Synonyms
  • HsT17432
• GenBank acession
  • BC012986
• Locus
  15q22.31
• Discovery year
  1997-08-22
• Entrez gene record
  4091
• Pubmed identfication
  • 9256479
• RefSeq identity
  • NM_005585
• Classification
  • SMAD family
• VEGA ID
  OTTHUMG00000133218
• Locus Specific Databases
  • The Globin Gene Server

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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