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14 3 3 sigma Antibody ALEXA FLUOR

14 3 3 sigma Antibody ALEXA FLUOR is available 0 time from Bioss primary conjugated antibodies. alexa fluor labs

Modification Unmodified
Clonality Polyclonal
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human 14-3-3 sigma
Specificity This is a highly specific antibody against 14-3-3 sigma.
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratin; YWHAS.
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 2810
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
Concentration 1ug per 1ul
Target Antigen 14-3-3 sigma
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Gene target14-3-3 sigma
Short name 14-3-3 sigma Antibody,
Technique Antibody
Alternative technique antibodies
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14 3 3 sigma Antibody ALEXA FLUOR - Gentaur.com
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