4-1BBL, human recombinant

• Catalog number
  4369-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  TNFSF9, CD137L
• Alternative_names
  TNFSF9, CD137L
• Description
  A transmembrane cytokine
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Biological activity
  Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED₅₀ for the effect is less than 10 ng/ml. Please note: results may vary with PBMC donors.
• Results
  10 ng/ml
• Molecular Weight
  19.5 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 5 mM Tris, pH 8.0 + 75 mM NaCl.
• Reconstitution Instructions
  We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  Human 4-1BB Ligand (4-1BBL) is a member of the emerging family of Ligands with structural homology to tumor necrosis factor. Recombinant human 4-1BBL is a 19.5 kDa protein containing 185 amino acid residues, comprising the TNF-like extra-Cellular domain of 4-1BBL.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  4-1BBL  
• Gene symbol
  TNFSF9, MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4, MIR941-4, PIRC19
• Short name
  4-1BBL, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  4-1BBL, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11939
• Gene
  TNFSF9
• Long gene name
  TNF superfamily member 9
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 9
• Synonyms
  • 4-1BB-L
  • 4-1BBL
  • CD137L
• Synonyms name
  • receptor 4-1BB ligand
  • homolog of mouse 4-1BB-L
  • CD137 ligand
• GenBank acession
  • U03398
• Locus
  19p13.3
• Discovery year
  1998-12-04
• Entrez gene record
  8744
• Pubmed identfication
  • 8405064
  • 8088337
• RefSeq identity
  • NM_003811
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000181831

Gene info

• Identity
  HGNC:35296
• Gene
  MIR1302-4
• Long gene name
  microRNA 1302-4
• Synonyms gene
  • MIRN1302-4
• Synonyms
  • hsa-mir-1302-4
• Locus
  2q33.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302130
• RefSeq identity
  • NR_031633
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37522
• Gene
  PIRC18
• Long gene name
  piwi-interacting RNA cluster 18
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313906
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37520
• Gene
  PIRC16
• Long gene name
  piwi-interacting RNA cluster 16
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313849
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32992
• Gene
  SNORD114-4
• Long gene name
  small nucleolar RNA, C/D box 114-4
• Synonyms
  • 14q(II-4)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767580
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003196.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5809
• Gene
  IGKV2OR2-4
• Long gene name
  immunoglobulin kappa variable 2/OR2-4 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-4
  • immunoglobulin kappa variable 2/OR2-4 pseudogene
• Synonyms
  • IGKV2/OR2-4
• GenBank acession
  • X51883
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28858
• Pubmed identfication
  • 2111145
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:33687
• Gene
  MIR941-4
• Long gene name
  microRNA 941-4
• Synonyms gene
  • MIRN941-4
• Synonyms
  • hsa-mir-941-4
• Locus
  20q13.33
• Discovery year
  2007-10-24
• Entrez gene record
  100126330
• RefSeq identity
  • NR_040032
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:37523
• Gene
  PIRC19
• Long gene name
  piwi-interacting RNA cluster 19
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313926
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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