Human CellExp™ 4-1BB / TNFRSF9, Fc Tag, Human Recombinant
-
Catalog numberP1306-50
-
PricePlease ask
-
Size50 ug
-
-
SynonymsTNFRSF9,4-1BB,CD137,CDw137,ILA
-
Alternative_namesTNFRSF9,4-1BB,CD137,CDw137,ILA
-
DescriptionA transmembrane cytokine
-
RecombinantYes
-
SourceHEK 293 cells
-
Purity by SDS PAGE≥95%
-
AssaySDS-PAGE
-
Endotoxin Level< 1 EU/ug
-
Activity Specifications test methodMeasured by its binding ability in a functional ELISA
-
Biological activityImmobilized Human 4-1BB, Fc Tag at 0.1 ug/mL (100 uL/well) can bind Biotinylated Human 4-1BB Ligand, Fc Tag, Avi Tag with a linear range of 0.4-13 ng/mL
-
Binding CapacityImmobilized Human 4-1BB, Fc Tag at 0.1 ug/mL (100 uL/well) can bind Biotinylated Human 4-1BB Ligand, Fc Tag, Avi Tag with a linear range of 0.4-13 ng/mL
-
Molecular Weight43.3 kDa
-
Storage Temp-20°C
-
ShippingGel pack
-
Shelf Life12 months
-
AppearanceLyophilized
-
Physical form descriptionLyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.
-
Reconstitution InstructionsReconstitute in sterile deionized water to a concentration of 50 µg/ml.
-
Background Information4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF. responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolTNFRSF9, TNFSF9, MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4, MIR941-4
-
Short nameCellExp™ 4-1BB / TNFRSF9, Fc Tag, Recombinant
-
TechniqueRecombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
LabelFc Tag
-
SpeciesHumans
-
Alternative nameH. sapiens CellExp™ 4-1BB / tumor necrosis factor receptor superfamily, member 9, fragment c detection labelled, H. sapiens Rec.
-
Alternative techniquerec
-
Alternative to gene targettumor necrosis factor receptor superfamily, member 9, 4-1BB and CD137 and CDw137 and ILA, TNFRSF9 and IDBG-88268 and ENSG00000049249 and 3604, cytokine binding, Extracellular, Tnfrsf9 and IDBG-205902 and ENSMUSG00000028965 and 21942, BT.49346 and IDBG-633668 and ENSBTAG00000003313 and 520341
-
Gene info
-
Identity
-
Gene
-
Long gene nameTNF receptor superfamily member 9
-
Synonyms gene
-
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 9
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1996-06-12
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameTNF superfamily member 9
-
Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 9
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1998-12-04
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Tumor necrosis factor superfamily
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1302-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1302 family
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 18
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 16
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-4
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin kappa variable 2/OR2-4 (pseudogene)
-
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-18
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Immunoglobulin kappa (IGK) orphons
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 941-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNAs
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
