TNF-Related Apoptosis Inducing Ligand (TRAIL) Anti-Human, Biotin

• Catalog number
  K0112979
• Price
  Please ask
• Size
  1X50ug

• Data Sheet URL
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. This 1 is suited for programmed cell-death studies. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Test
  Koma Biotech supplies antibodies that are for research of human proteins.
• Properties
  Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Conjugation
  Biotinylated
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  TNF-Related   Ligand   TRAIL  
• Gene symbol
  TNF, TNFRSF1A, TNFRSF1B, LTBR, TNFSF10, TNFRSF10B
• Short name
  TNF- Apoptosis Ligand (TRAIL) Anti- ,
• Technique
  anti-Human, apoptosis, anti-, anti, antibody to, antibodies, antibodies against human proteins, apoptosis pathway
• Label
  Biotin
• Species
  Human, Humans
• Alternative name
  tumor necrosis factor-Related programmed cellular destruction Inducing Ligand (TRAIL) Antibody toHuman, biotinilated
• Alternative technique
  celldeath, antibodies
• Alternative to gene target
  tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:11925
• Gene
  TNFSF10
• Long gene name
  TNF superfamily member 10
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 10
• Synonyms
  • TRAIL
  • Apo-2L
  • TL2
  • CD253
• GenBank acession
  • U37518
• Locus
  3q26
• Discovery year
  1998-12-04
• Pubmed identfication
  • 8777713
  • 8663110
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000156917

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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