Human CellExp™ VEGF R3 / FLT4, Fc Tag, Mouse Recombinant

• Catalog number
  P1405-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL
• Alternative_names
  Flt-4, FLT4, LMPH1A, PCLFLT41, VEGFR3, VEGFR-3, FLT-4, FLT-41, FLT41, PCL
• Description
  Cell-surface receptor for VEGFC and VEGFD
• Recombinant
  True
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >95%
• Assay
  SDS-PAGE.
• Endotoxin Level
  Less than 0.1 EU per ug by the LAL method.
• Activity Specifications test method
  Immobilized Human VEGF-C, His Tag at 5 ug/mL (100 uL/well) can bind Mouse VEGF R3, Mouse Fc Tag, low endotoxin with a linear range of 1-10 ng/mL
• Binding Capacity
  Immobilized Human VEGF-C, His Tag at 5 ug/mL (100 uL/well) can bind Mouse VEGF R3, Mouse Fc Tag, low endotoxin with a linear range of 1-10 ng/mL
• Molecular Weight
  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 116-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized powder
• Physical form description
  Lyophilized
• Reconstitution Instructions
  Reconstitute in sterile deionized water to the desired protein concentration.
• Background Information
  Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.
• Amino acid sequence
  Tyr 25 - Asp 770
• Handling
  Centrifuge the vial prior to opening.
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   VEGF   FLT4   Tag  
• Gene symbol
  VEGFA, VEGFD, VEGFC, FLT4
• Short name
  CellExp™ VEGF R3 / FLT4, Fc Tag, Mouse Recombinant
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  Fc Tag
• Species
  Humans, Mouses
• Alternative name
  H. sapiens CellExp™ VEGF R3 / FLT4, fragment c detection labelled, Mouse Rec.
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:12680
• Gene
  VEGFA
• Long gene name
  vascular endothelial growth factor A
• Synonyms gene
  • VEGF
• Synonyms gene name
  • vascular endothelial growth factor
• Synonyms
  • VEGF-A
  • VPF
• GenBank acession
  • AB021221
• Locus
  6p21.1
• Discovery year
  1994-01-10
• Entrez gene record
  7422
• Pubmed identfication
  • 8786112
• RefSeq identity
  • NM_001025366
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000014745
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:3708
• Gene
  VEGFD
• Long gene name
  vascular endothelial growth factor D
• Synonyms gene
  • FIGF
• Synonyms gene name
  • c-fos induced growth factor (vascular endothelial growth factor D)
• Synonyms
  • VEGF-D
• GenBank acession
  • AJ000185
• Locus
  Xp22.2
• Discovery year
  1997-03-27
• Entrez gene record
  2277
• Pubmed identfication
  • 9479493
• RefSeq identity
  • NM_004469
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000021175
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:12682
• Gene
  VEGFC
• Long gene name
  vascular endothelial growth factor C
• Synonyms
  • VRP
  • VEGF-C
• Synonyms name
  • vascular endothelial growth factor-related protein
• GenBank acession
  • BC035212
• Locus
  4q34.3
• Discovery year
  1996-10-26
• Entrez gene record
  7424
• Pubmed identfication
  • 8617204
• RefSeq identity
  • NM_005429
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000160734

Gene info

• Identity
  HGNC:3767
• Gene
  FLT4
• Long gene name
  fms related receptor tyrosine kinase 4
• Synonyms gene name
  • fms-related tyrosine kinase 4
  • fms related tyrosine kinase 4
• Synonyms
  • VEGFR3
  • PCL
  • VEGFR-3
• Synonyms name
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • primary congenital lymphedema
• GenBank acession
  • X68203
• Locus
  5q35.3
• Discovery year
  1991-10-25
• Entrez gene record
  2324
• Pubmed identfication
  • 1319394
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000130931

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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